Serevent is a synthetic drug related in chemical structure to phenyl-substituted β-amino alcohols, for administration by inhalation. Salmeterol refers to selective beta2-adrenoreceptor agonists group with long-lasting bronchodilatory action. According to its chemical composition, as well as other beta2-agonists, it is a racemate of two enantiomers (S-salmeterol and R-salmeterol). Salmeterol was created in 80s years of the twentieth century in GlaxoSmithKline laboratory, UK, and is used in clinical practice since 90s years of the twentieth century….
Category: Anti-allergic/Asthma - Part 2
The main contraindications are: children under 4 years old; hypersensitivity to drug components. [ithshop code=”advair” tpl=”short” page_id=”969″ dummy=”txt”] With Caution As with all inhaled medication containing glucocorticosteroids, Advair ( what is it? ) should be used with caution by patients with acute or latent pulmonary tuberculosis. thyrotoxicosis. fungal, viral or bacterial respiratory system infections. When you receive any drug of sympathomimetic group, particularly in does higher than therapeutic, development of cardiovascular complications such as increase in systolic arterial…
Children after 12 years old and adults are recommended the following drug dosages:
- 4 inhalation a day at the rate of 50 mcg of salmeterol / 100 mcg of fluticasone – twice over;
- 4 Advair doses a day at the rate of 50 mcg of salmeterol / 250 mcg of fluticasone – twice over;
- 4 inhalations a day at the rate of 50 mcg of salmeterol / 500 mcg of fluticasone – twice over.
Children of 4 -12 years old are recommended the following Advair dosage – 4 inhalations a day at the rate of 50 mcg of salmeterol / 100 mcg of fluticasone – twice over. At COPD adults are appoint no more than 4 inhalations a day – 50 mcg of salmeterol / 500 mcg of fluticasone. Inhalations are carried out twice a day.
[ithshop code=”advair” tpl=”short” page_id=”969″ dummy=”txt”]
If 2 times a day administration provides symptoms control, as part of dosage reduction to lowest effective it is possible to decrease dosage frequency to 1 times a day.
The patient should be prescribed such a fluticasone propionate dose corresponding to the disease.
If treatment with inhaled glucocorticosteroids does not provide adequate disease control, their replacement with Advair at a dose, therapeutically equivalent to glucocorticosteroids dose, may improve bronchial asthma control. Patients who can control asthma using only inhaled glucocorticosteroids, their replacement with Advair may allow reducing glucocorticosteroids dose, necessary for asthma control.
Advair (learn more) reviews confirm that elderly patients and those who have kidneys and liver abnormalities do not require treatment regimen correction.
Expected salmeterol overdose signs and symptoms are typical of excessive beta2-adrenergic stimulation and include:
- increased systolic arterial blood pressure;
Acute fluticasone propionate overdose when inhaled can cause temporary hypothalamo-pituitary-adrenal axis suppression. Usually, it doesn’t require any extra-measures because the normal adrenal function is restored within a few days.
When receiving the drug in doses higher than recommended for a long period of time, a significant inhibition of adrenocortical function is possible. There were rare cases of acute adrenal crisis, which occurred mostly in children treated with doses higher than recommended for a long time (months or years). Acute adrenal crisis manifests in hypoglycemia accompanied by confusion and/or convulsions. Situations, that can serve as triggering factors for the acute adrenal crisis, include:
- any rapid dosage reduction of fluticasone propionate.
There is no specific treatment for salmeterol and fluticasone propionate overdose. In case of overdose supportive therapy should be carried out, as well as patient’s condition observation. At chronic overdose reserve, adrenocortical function control is recommended.
Advair Diskus is a drug used for bronchial asthma and obstructive pulmonary diseases treatment. There are two components – included in drug composition – fluticasone and salmeterol – provide a bronchodilatory, antiasthmatic and anti-inflammatory effect. The first substance is a glucocorticosteroid, which differs favorably from other means of this group when using inhaled – fluticasone does not affect human hormone system condition, especially adrenal cortex hormones. Thus, being not inferior to other glucocorticosteroids in anti-inflammatory…
The most common side effects of Ventolin are: skeletal muscles tremor; headache; peripheral blood vessels expansion; rapid heartbeat. [ithshop code=”ventolin” tpl=”short” page_id=”683″ dummy=”txt”] There may develop but very rarely hypersensitivity reactions: angioedema; urticaria; bronchospasm; hypotension; collapse; muscle cramps; tachycardia. Inhaled medicines may cause paradoxical bronchospasm. Paradoxical bronchospasm should be immediately arrested with a different formulation of Ventolin inhaler or another fast-acting bronchodilator. You should immediately discontinue Ventolin use, estimate patient’s condition, conduct necessary examinations and…
Adults (including elderly patients): ordinary starting dose of inhaled salbutamol is 2.5 mg. It can be raised to 5 mg. Repeated inhalation can be up to 4 times a day. For adult patients’ treatment with severe airway obstruction dose may be increased to 40 mg per day, however, this treatment should be carried out in stationary conditions under careful medical supervision. [ithshop code=”ventolin” tpl=”short” page_id=”683″ dummy=”txt”] Children aged from 4 to 11 years. The usual…
Ventolin inhaler generics are popular all over the world especially Salbutamol. Salbutamol inhibits histamine release from mast cells, leukotrienes, prostaglandin D2 and other biologically active substances for a long time. It inhibits early and late bronchial reactivity. It has a pronounced bronchodilator effect of preventing or arresting bronchospasm, reduces airways resistance. It increases lung capacity. Also, Ventolin inhaler increases mucociliary clearance (in chronic bronchitis to 36%), stimulates mucus secretion, activates ciliated epithelium function.
[ithshop code=”ventolin” tpl=”short” page_id=”683″ dummy=”txt”]
It arrests inflammatory mediators release from mast cells and basophils, in particular, histamine release induced by anti-immunoglobulin E, removes suppression of antigen mucociliary transport and neutrophil chemotactic factor release. It prevents the development of allergen-induced bronchospasm. Salbutamol online also reduce the number of β1-adrenergic receptors, including lymphocytes.
It has a number of metabolic effects:
- reduces potassium concentration in plasma.
- affects glycogenolysis and insulin release.
- has a hyperglycemic (especially in patients with bronchial asthma) and lipolytic effect.
- increases acidosis risk.
If the medication is taken according to recommended therapeutic doses there is no risk of adverse reactions appearance on cardiovascular system, it does not cause blood pressure increase. To a lesser extent, as compared with the drugs of this group this drug has a positive chronotropic and inotropic effects. It influences coronary arteries extension.
Once Salbutamol is inhaled action develops rapidly, the effect starts in 5 min, max – after 30-90 min (75% of the maximum effect is reached within 5 min), duration – 4.6 hours.
Here is the list of Ventolin Generics produced by various countries worldwide including Great Britain, Germany, India, Slovenia and etc.:
- Ventolin Nebule;
- Salamol Steri-Neb;
- Cybutol Cyclocaps.
These generics are available at My Canadian Pharmacy online. Our team of professionals will be glad to accept your order and deliver to you medications as fast as possible. Do not waste time and command our service right now. Discounts and Sales are valid for you!
Ventolin is an inhaler directed to arrest asthma attacks. Its active ingredient is Salbutamol (daily dose is 2, 5 mg). Other additive constituents are sodium chloride, diluted sulfuric acid, and purified water. This inhaler is considered to be one of the most effective medications applied and prescribed for asthma attacks treatment. Ventolin may be ordered online via My Canadian Pharmacy. [ithshop code=”ventolin” tpl=”short” page_id=”683″ dummy=”txt”] Pharmacological Properties Pharmacodynamics Salbutamol is 2- selective adrenoreceptor agonist. At…