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Asthma, Chronic Obstructive Pulmonary Disease, COPD, Bronchitis, Emphysema, Breathing
Advair Generic names:
Fluticasone/Salmeterol, Seretide, Viani, Adoair, ForAir, advair diskus, Seroflo
What is Canadian Pharmacy Advair?
Canadian Advair is a drug used as a means for bronchospasm relief.
Advair drug used to treat COPD diseases. The drug is recommended to patients that use inhaled glucocorticosteroids in their therapy, and those patients whom glucocorticosteroids do not bring symptoms relief.
It should be remembered that this drug requires a sufficiently long-term reception for diseases treatment, as well as preventive care. Do not discontinue Advair usage in case of temporary health state improvement and disease symptoms disappearance. Read a detailed description of what Canadian Pharmacy Advair is…
Generics of Canadian Pharmacy Advair
Canadian Pharmacy Advair consists of: salmeterol xinafoate – to eliminate symptoms – and fluticasone propionate – to improve respiratory function. Also: fluticasone prevent disease exacerbations. Lactose is used as powder inhaler filling material.
Pharmacy chains offer some medications that can replaced Advair in accordance with a physician approval: Berodual, Berodual H, Symbicort Turbuhaler, etc.
Canadian Pharmacy Advair Dosage
This medicinal product is intended for inhalation. Dosage depends on patient’s condition severity and age.
- Children aged 4 – 12 years are recommended two inhalations a day at the rate of 25 mcg of salmeterol and 50 mcg of fluticasone.
- Adults and adolescents aged 12 years and older are recommended to use drug twice a day at the rate of 25 mcg of salmeterol and 50 mcg of fluticasone or 25 mcg of salmeterol and 125 mcg of fluticasone.
- The third option of dosage – at the rate of 25 mcg of salmeterol and 250 mcg of fluticasone.
It is important to remember: at all dosage options inhalation must be carried out twice a day.
You need to know that at present moment there is no information on Canadian Advair overdose. There is information only about its components overdose.
Salmeterol overdose causes tremor and headaches, while fluticasone suppresses adrenal function. In the first case it is necessary to withdraw Advair drug, in the second – it is allowed to continue treatment with the drug. This is due to the fact that adrenal function independently recovered in a few days.
In pharmacies the drug is released only on physician prescription. More detailes about Advair dosage…
For this medication two kinds of possible adverse symptoms are characteristic, which are related to each of its components. Fluticasone may cause paradoxical bronchospasm, hoarseness, mouth or throat candidosis. Salmeterol can affect cardiovascular system – violate heart rate, cause headaches (of vascular origin). There possible allergic reactions on the substance such as angioneurotic shock or rash.
Patients, treated from COPD, can obtain pneumonia. In addition, Canadian Pharmacy Advair can cause:
- mouth and throat irritation;
- abdominal pains;
- taste disorders;
- muscle spasms;
- in rare cases – sleep disorders, behavioral disorders, including irritability and hyperactivity – in most cases these symptoms are observed at children.
According to instruction Canadian Advair is contraindicated to children under 4 years old, patients who have allergy to drug components. Advair is prescribed with caution for:
- respiratory tract infections of fungal, viral or bacterial origin;
- uncontrolled arterial hypertension;
- pulmonary tuberculosis;
- ischemic heart disease;
- hypertrophic subaortic stenosis;
- lactation period;
- pregnancy… See a full list of Canadian Pharmacy Advair contraindications…
Because of bronchospasm risk it is recommended to avoid selective and non-selective beta-adrenergic blocking agent, except for cases where they are essential.
In normal situations fluticasone propionate inhalations are accompanied by its low concentrations in blood plasma due to intensive metabolism during «first pass» and high systemic clearance under cytochrome P450 CYP3A4 isoenzyme influence in intestinal tract and liver. Due to this clinically significant interactions involving fluticasone propionate are unlikely.
Drug interactions research has shown that ritonavir – a highly active CYP3A4 isoenzyme inhibitor – can cause a sharp increase in fluticasone propionate concentration in blood plasma, resulting in significantly reduced serum cortisol concentrations. During post-approval observations there were received reports of clinically significant drug interactions at patients receiving fluticasone propionate (intranasally or by inhalation) together with ritonavir. This interaction causes side effects such as Cushing’s syndrome and adrenal function suppression. Given this, it is recommended to avoid simultaneous use of fluticasone propionate and ritonavir, unless potential benefit to patient outweighs risk of glucocorticosteroids systemic side effects.
Studies have shown that other CYP3A4 inhibitors produce negligible (erythromycin) and minor (ketoconazole) increased fluticasone propionate content in blood plasma, with almost no decrease in serum cortisol concentrations. Despite this, it is advisable to be careful while applying fluticasone propionate and potent CYP3A4 inhibitors (e. g., ketoconazole), since such combinations do not exclude probability of increased fluticasone propionate concentration in blood plasma, which could potentially increase systemic fluticasone propionate effects.
When studying drug interactions it was found that ketoconazole use as concomitant systemic therapy salmeterol concentration in blood plasma significantly increases. This can lead to QTc interval lengthening. Caution must be performed at combined use of potent CYP3A4 inhibitors (e. g., ketoconazole) and salmeterol.
Xanthine derivatives, glucocorticosteroids and diuretics increase hypokalemia risk (especially at patients with acute bronchial asthma exacerbations, during hypoxia).
MAO inhibitors and tricyclic antidepressants increase side effects risk for cardiovascular system.
Advair Canadian Pharmacy and Alcohol
Doctors always insist on avoiding or limiting alcohol consumption when taking medications. In the case of Advair, it is not known whether alcohol causes side effects or slows down drug effects. Advair consists of two active ingredients: fluticasone and salmeterol. Combining fluticasone and alcohol causes no adverse reaction. Salmeterol – bronchodilator – may cause increased heartbeat. Large amounts of alcohol together with salmeterol may cause chances in rapid heartbeat or tachycardia.