Canadian Pharmacy Advair is a combined medication containing salmeterol and fluticasone propionate which have different mechanisms of action. Salmeterol prevents bronchospasm symptoms, fluticasone propionate improves pulmonary function and prevents exacerbations. Advair Canada drug due to more convenient dosage regimen may be an alternative for patients who at the same time receive beta2-adrenoceptor agonists and inhaled glucocorticosteroids in different inhalers.
There are no evidence that co-administration of inhaled salmeterol and fluticasone propionate affects pharmacokinetics of each other, and therefore, pharmacokinetic characteristics of each Advair drug component can be considered separately.
Application and Dosage Regimen
Canadian Advair drug is used only for inhalation.
Patients should be informed that in order to achieve optimal effect the drug should be used regularly, even if clinical symptoms of asthma and COPD are absent.
Doctor should regularly assess patient’s treatment effectiveness.
Determination of therapy duration and dosage changes is possible only according to doctor’s advice.
Advair Canada Pharmacy drug dosage should be reduced to minimal that provides effective symptoms control.
If Advair drug 2 times a day administration provides symptoms control, as part of dosage reduction to lowest effective it is possible to decrease dosage frequency to 1 times a day.
Patient should be prescribed such a fluticasone propionate dose corresponding to disease severity.
Children after 12 years old and adults are recommended the following drug dosages:
- 4 inhalation a day at the rate of 50 mcg of salmeterol / 100 mcg of fluticasone – twice over;
- 4 Advair doses a day at the rate of 50 mcg of salmeterol / 250 mcg of fluticasone – twice over;
- 4 inhalations a day at the rate of 50 mcg of salmeterol / 500 mcg of fluticasone – twice over.
Children of 4 -12 years old are recommended the following Advair dosage – 4 inhalations a day at the rate of 50 mcg of salmeterol / 100 mcg of fluticasone – twice over.
At COPD adults are appoint no more than 4 inhalations a day – 50 mcg of salmeterol / 500 mcg of fluticasone. Inhalations are carried out twice a day.
Canadian Pharmacy Advair (learn more) reviews confirm that elderly patients and those who have kidneys and liver abnormalities does not require treatment regimen correction.
Administration of doses higher than those specified in «Dosage» section is not recommend. It is important to regularly review patient’s dosage regimen and reduce dosage to the lowest recommended for ensuring effective symptoms control.
Expected salmeterol overdose signs and symptoms are typical of excessive beta2-adrenergic stimulation and include:
- increased systolic arterial blood pressure;
Acute fluticasone propionate overdose when inhaled can cause temporary hypothalamo-pituitary-adrenal axis suppression. Usually it doesn’t require any extra-measures because normal adrenal function is restored within a few days.
When receiving the drug in doses higher than recommended for a long period of time, a significant inhibition of adrenocortical function is possible. There were rare cases of acute adrenal crisis, which occurred mostly at children treated with doses higher than recommended for a long time (months or years). Acute adrenal crisis manifests in hypoglycemia accompanied by confusion and / or convulsions. Situations, that can serve as triggering factors for acute adrenal crisis, include:
- any rapid dosage reduction of fluticasone propionate.
There is no specific treatment for salmeterol and fluticasone propionate overdose. In case of overdose supportive therapy should be carried out, as well as patient’s condition observation. At chronic overdose reserve adrenocortical function control is recommended.