Types of Drugs for Asthma Treatment
At therapeutic treatment of bronchial asthma disease, drugs are divided into two main types.
Drugs of the first group are commonly used to eliminate asthmatic bronchial spasm.
These bronchodilators, familiar to all asthmatics, are issued in the form of inhalers and in the form of pills or capsules. When patient with asthma receives only these drugs, occasionally he cannot cope with attacks, and has to call an ambulance, and sometimes be hospitalized.
Asthma only progresses, the need for inhalers increases – this can result in invalidity. This happens when doctor considers asthma as obstructive bronchitis disease and chooses drugs to eliminate spasm. But about 16 years ago asthma began to be regarded as chronic inflammatory pulmonary disease, which manifests itself in the form of dyspnea, coughing and asthma attacks. This approach allowed using other medications for asthma treatment.
Drugs of the second group are used at basic asthma treatment, suppressing and inhibiting inflammation process that takes place in bronchi, preparing to bronchospasm – so it will be possible to control asthma. This group includes:
- non-steroidal anti-inflammatory inhalers;
- antileukotriene drugs;
- steroid inhalers, preventing inflammation;
- long-lasting bronchodilator inhalers, virtually affecting inflammation;
- compound drugs that combine both these components.
Canadian Pharmacy Serevent
Salmeterol (Lat. Salmeterolum) is a synthetic drug related in chemical structure to phenylsubstituted β-aminoalcohols, for administration by inhalation. Salmeterol refers to selective beta2-adrenoreceptor agonists group with long-lasting bronchodilatory action. According to its chemical composition, as well as other beta2-agonists, it is a racemate of two enantiomers (S-salmeterol and R-salmeterol). Salmeterol was created in 80s years of the twentieth century in GlaxoSmithKline laboratory, UK, and is used in clinical practice since 90s years of the twentieth century, originally under trademark «Serevent».
Drug mechanism of action is stimulation of beta2-adrenoceptors in bronchial smooth muscle through intracellular adenylate cyclase activation, which forms a complex with G-protein, under the influence of which cAMP formation and of protein kinase A stimulation increases, leading to internal organs smooth muscle relaxation. Serevent is a noncompetitive beta2-adrenoceptor antagonist, which provides drug high selectivity and long-lasting action (until 12:00 after inhalation). Canadian Pharmacy Serevent is not a complete beta2-adrenoceptor agonist, which leads to small delay in drug action onset, but to fewer side effects. Serevent inhalation affects only beta2- adrenoceptors in bronchi and does not affect receptors in other organs. Serevent only slightly affects myocardial beta1-adrenoceptors.
At long-term use of Canada healthcare Serevent, drug tolerance development is observed, and significantly exceeding average therapeutic dosage greatly increases serious adverse effects probability, including those associated with myocardial adrenoreceptors activation (including tachycardia, atrial fibrillation, myocardial ischemia, orthostatic hypotension, QT interval prolongation), and possibility of «ricochet» effect occurrence (although lower than with other adrenoceptor agonists) – increased bronchospasm at excess average therapeutic dosage or too frequent drug use. For increasing Serevent Canadian Pharmacy effect it is recommended to use it together with inhaled corticosteroids. Serevent is not indicated for acute asthma attacks relief due to relatively slow onset of action.
Canadian Serevent is rapidly absorbed in respiratory tract after administration by inhalation, onset of action is observed within 10 – 20 minutes after drug inhalation and lasts until 12 hours. Serevent does not create high concentrations in blood and internal organs, according to research, the drug passes through placental barrier and is excreted in breast milk. The drug is metabolized in liver to inactive metabolites. Canadian Caremall Serevent is excreted primarily with feces, partly with urine. Half-life period is 5,5 hours, complete drug clearance is observed within 72 hours.
Serevent Canada is used at bronchial asthma and chronic obstructive pulmonary diseases by inhalation for long-term airway obstruction treatment, including night asthma attacks, and asthma attacks after exercise prevention.
- For asthma attacks prevention, including at night, usual dosage for adults and children over 12 years – 2 inhalations (50 mcg) twice a day (morning and evening).
- For bronchospasm provoked by exercise prevention – 2 inhalations at least 30 – 60 minutes before exercise.
- For severe asthma treatment – 100 mcg 2 times a day.
Precautions: not applicable for bronchospasm relief. With caution prescribed to patients with thyrotoxicosis, severe asthma, hypoxia of any origin.
Therapeutic effect may be reduced when inhaler is cooled.
If recommended dosage is not effective, you need to increase it. It should be understood that regular Serevent use, at most patients, need for additional short-lasting sympathomimetics use reduces.
Do not allow contact with eyes.
When using Canadian Pharmacy Serevent frequency of side effects occurrence is small. Overall side effects incidence when using the drug is 16%; common side effects (headaches, seizures, tremors, tachycardia) are observed with frequency of 1,5 – 3% with 50 mcg and 7 – 8 % with 100 mcg. Other side effects occur rarely:
- allergic reactions (skin rash, itching, urticaria fever, Quincke’s edema);
- stomatitis and pharyngitis due to mucous membranes irritation;
- arrhythmia (including atrial fibrillation, supraventricular tachycardia and extrasystoles);
- paradoxical bronchospasm;
Canadian Serevent is contraindicated in case of hypersensitivity to its components. The drug should be used with caution in case of:
- lactation period;
Serevent is used at children older than 4 years.
Serevent is available as aerosol in dosage of 25 mcg/dose containing 60 and 120 doses, and in powder for inhalation in discus in 50 mcg/dose containing 4 doses. Canadian healthcare Serevent is also available in combination with fluticasone in the form of aerosol or powder for inhalation in discus.
Prohibition for Use in Sports
Serevent is prohibited for use to athletes during competitions by World Anti-Doping Agency (https://www.wada-ama.org/). But some athletes with asthma have permission for drug use.
How to Choose Drugs for Asthma Treatment
Doctor’s task is to choose optimal combination of drugs from the first and second group, described above, and then asthma will be under control. Additional immunological treatment will improve patient’s condition. Patients should not be afraid of preparations for inhalation, as they are means for local effects on bronchi, the same as cream for skin – no one is afraid to use cream or ointment.
This article doesn’t contain information about hormonal drugs, that are ingested systemically, because today it is considered wrong to treat asthma with such means.