What is Viagra Super Force?

Viagra Super Force is a drug used to treat erectile dysfunction and premature ejaculation.

Viagra Super Force medication is based on:

• Dapoxetine (60 mg), which contributes to premature ejaculation treatment;
• Sildenafil (100 mg), which copes with erectile dysfunction.

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Description

Viagra Super Force is classified as an oral medication for male sexual dysfunction. It not only acts as preventive means but also as erectile disorders treatment. It was particularly appreciated by men who cannot perform long-lasting sexual intercourse.

Each pill contains 100 mg of Sildenafil and 60 mg of Dapoxetine. The drug acts during 4 – 5 hours. The effect can be expected within 40 minutes after administration. Pills have a bitter taste. It is forbidden to take medication with alcohol.

Viagra Super Force can be called «Super-Viagra». The drug is an excellent choice for those who want to extend sexual intercourse duration and increase potency.

Pharmacological Effect

Sildenafil is a powerful selective cyclic guanosine monophosphate (cGMP) – specific phosphodiesterase type 5 (PDE-5) – inhibitor.

Mechanism of Action

Physiological erection mechanism is directly connected to the reaction, during which, at sexual stimulation, nitric oxide (NO) in cavernous bodies is released. Reaction stimulates cGMP level increase followed by blood flow stimulation and cavernous bodies smooth muscle relaxation.

Active ingredient of Viagra Super Force has an indirect influence on the process, not acting directly on the cavernous body, it only enhances nitric oxide effect by means of inhibiting PDE-5, which leads to cGMP breakdown.

Sildenafil is selective against PDE-5 in vitro, its activity against PDE-5 surpasses activity against other known phosphodiesterase isoenzymes: PDE-6 – 10 times; PDE-1 – more than 80 times; PDE-2, PDE-4, PDE-7-PDE-11 – more than 700 times. Sildenafil 4000 times more selective against PDE-5 compared to PDE-3, it is important because PDE-3 is one of the main enzymes that are involved in cardiac contractility regulation.

To achieve Sildenafil effectiveness sexual stimulation is required.

Pharmacokinetics

Pharmacokinetics in recommended dosage range is linear.

Elderly patients

Patients in the age group older than 65 years Sildenafil clearance is reduced and its free concentration in blood plasma is about 40% higher than in patients of 18 – 45 years old. Patient’s age has no significant clinical impact on side effects incidence.

Renal function disorders

At mild (creatinine clearance (CC) is 50-80 ml/min) or moderately severe (creatinine clearance is 30-49 ml/min) renal insufficiency, pharmacokinetics, in case of drug single dose 50 mg, will not change. If the patient has severe renal insufficiency.

At patients with cirrhosis (stages A and B, according to Child-Pugh classification) Sildenafil clearance is reduced, there is AUC (84%) and Cmax (47%) indicators increase in comparison with those of patients of the same age group, but with normal hepatic function. Sildenafil pharmacokinetics in patients with severe hepatic function disorders (stage C according to Child-Pugh classification) was not studied.

Indications

Viagra Super Force is indicated for erectile dysfunction treatment – inability to achieve or maintain penis erection sufficient for satisfactory sexual intercourse. Sildenafil efficacy of is achievable only with further sexual stimulation.

Dosage

The initial dosage of the product ranges from 25 to 100 mg a day. Experts recommend taking the drug 1 hours before planned sexual intercourse. It can be said that this means does not hurt the body, which implies it can be taken independently, without doctor’s prescription, you just have to read instructions and know all details and nuances, and then health problems will not occur.

Effect on the Body

We have already mentioned above, active ingredients of medication are Sildenafil citrate (100 mg) and Dapoxetine (60 mg). Sildenafil effect is characterized by penile muscles’ relaxation, thereby increasing blood flow to the penis. Dapoxetine slows down ejaculation process, it allows you to avoid premature ejaculation.

Clinical Data

Cardiac research

ECG data among healthy volunteers have shown that taking Sildenafil at dosages which do not exceed 100 mg, does not lead to clinically significant changes. Blood pressure change maximal indicators after taking substance in a dosage of 100 mg are as follows: systolic blood pressure decreased by 8,3 mm Hg, diastolic – by 5,3 mm Hg. Blood pressure data among patients who were taking nitrates are more pronounced, but also transient.

In a group of patients with severe ischemic heart disease (more than 70% of patients with at least one coronary artery stenosis) study of hemodynamic substance effect in the same dosage showed a reduction in systolic blood pressure by 7%, and diastolic – by 6%. Pulmonary systolic blood pressure indicator decreased by 9%. There was no evidence of any cardiac output or blood flow disorders in coronary arteries with stents. Sildenafil has led to increasing in adenosine-induced coronary flow both in stenotic and undamaged coronary arteries by approximately 13%.

Double-blind placebo-controlled study. 144 patients with erectile dysfunction and stable cardiac angina took anti-anginal medications (except for nitrates) and performed exercises until angina symptoms reduction. Patients who received a placebo instead of Sildenafil, performed physical exercise longer (19,9 sec.; 0,9 – 38,9 sec.).

Randomized, double-blind, placebo-controlled study determined the effect of variable Sildenafil dosing (100 mg) in a group of men (n = 568) with erectile dysfunction and arterial hypertension, who were taking more than two anti-hypertensive drugs.

As a result of studies, the following parameters were derived: in the group, receiving sildenafil, erection improved in 71% of men, whereas in the group, receiving a placebo – only in 18%. Adverse effects had the same frequency as that of other groups, as well as in those patients who received more than three anti-hypertensive drugs.

Visual impairment research

Farnsworth-Munsell 100 test found at some patients inability to distinguish between shades of blue / green colors an hour after 100 mg of Sildenafil ingestion. These changes had disappeared within two hours after administration. Such deviation happens due to participating in light transmission in retina PDE-6 inhibition. Impact on contrast perception, intraocular pressure, visual acuity and pupil diameter was not detected.

Placebo-controlled crossover study showed that 100 mg single dose was well tolerated by patients with proved early-aged macular degeneration (n = 9). Virtual visual tests (visual acuity, Amsler grid, color perception, colors passage simulation, Humphrey perimetry and photostress) showed no clinically significant changes in vision.

Efficiency

Viagra Super Force belongs to most powerful means of new generation. None of the drugs copes with erectile dysfunction as good as this one, and if it does it has a lot of contraindications.

Six months in twenty-one randomized, double-blind, placebo-controlled study of three thousand patients from 19 to 87 years with erectile dysfunction of various origins (organic, psychogenic or mixed) have helped scientists to collect data on Sildenafil efficacy and safety. In drug effectiveness study erection journal, patient’s partner survey and a questionnaire on sexual function status (International Erectile Function Index) were used.

Drug effectiveness was considered patient’s ability to achieve and maintain sexual excitement, which would be sufficient for satisfactory sexual intercourse. A positive result was achieved in all studies and confirmed by long-term year-long studies.

In groups where fixed dose of the drug was used, patients ratio, which reported on effectiveness of therapy, allowed obtaining these figures: 62% (dosage – 25 mg), 74% (dosage – 50 mg) and 82% (dosage – 100 mg) in comparison with 25% in placebo group. Questionnaire together with data on erectile function improvement showed that treatment with Sildenafil increases overall satisfaction with sexual intercourse and improves orgasm quality.

Among patients who reported improvement in potency with the help of treatment with Sildenafil, there were 59% of patients with diabetes, 43% of patients who underwent radical prostatectomy and 83% of patients with spinal cord injuries (vs. 16%, 15% and 12% in placebo group, respectively).

There was other medical research in human volunteers. All of them gave positive results and good performance. Worldwide, this means was recognized as the best, effective and safe.