What is Viagra?

Viagra is a medication released for erectile dysfunction treatment. The mechanism of the action is simple. The active ingredient sildenafil relaxes smooth muscles and stimulates blood flow into the penile cavernous bodies responsible for the erection. Under this drug influence, sexual intercourses will be longer, their number increases considerably during one night.

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In the case of natural sexual excitement, an erection occurs due to the blood accumulation in the penis. The pill will come into effect only when a person feels sexual excitement, and after the end of sexual intercourse, the penis will take a natural relaxed form.

Viagra should be taken strictly as your doctor advises. It should usually be taken 30 min to 1 hour before the sexual intercourse. The dosage should not exceed 1 tablet per day. The initial recommended dosage is 50 mg, taken orally. The maintenance dosage is 25 to 100 mg, taken orally, once a day.

Composition

Pharmacologic Effect

Sildenafil is a potent selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5).

The physiological mechanism of erection is associated with the nitric oxide release in the cavernous body during sexual stimulation. This, in turn, leads to an increase in the level of cGMP, subsequent relaxation of the cavernous bodies smooth muscle tissue and an increase in blood flow.

Sildenafil does not have a direct relaxing effect on an isolated cavernous body but enhances the effect of NO by suppressing PDE5, which is responsible for the cGMP degradation.

Sildenafil is selective for PDE5 in vitro, its activity against PDE5 is higher than that of other known isoenzymes of phosphodiesterase. Sildenafil is 4000 times more selective for PDE5 than with PDE3, which is of significant importance since PDE3 is one of the key enzymes in the myocardial contractility regulation.

A mandatory condition for the sildenafil effectiveness is sexual stimulation.

Advantages

• Viagra is now the first choice of doctors for treating erectile dysfunction, including for those who suffer from diabetes and when erectile dysfunction is induced by antidepressants;
• alternative application: pulmonary arterial hypertension treatment;
• treatment of altitude disease;
• a performance-enhancing drug for some sportsmen;
• affordable price;
• mild side effects which quantity is less than 2%;
• a great number of generics;
• a diversity of dosages.