Instruction for My Canadian Pharmacy Viagra Use

The active substance: Sildenafil Citrate
Administration: The drug is used to increase potency and is applied at erectile dysfunction treatment.
Viagra Pills: coated light blue, diamond-shaped, slightly convex pills with cut and round edges.
Viagra is released in 25, 50 and 100 pills.
Viagra composition is cellulose, magnesium stearate, calcium hydrogen phosphate anhydrous, croscarmellose sodium.

Viagra Description

Dosage and Instruction for Use

Take orally half an hour before sexual intercourse. The daily recommended dosage is 100 mg but it can be correspondingly reduced to 50 and 25 mg considering individual medication tolerance. The daily dose of 100 mg taken no more than once a day.

Viagra Action

Viagra is proven and most convenient drug for ED treatment. This medication is selective inhibitor of specific phosphodiesterase sGMF 5 (PDE5).

Viagra performs with sexual stimulation presence only. Viagra does not contribute to visual loss syndrome and has no effect on intraocular pressure, pupil size.

Sildenafil has no direct relaxing effect on isolated corpus cavernosum, but enhances the relaxing effect of the nitric oxide – NO on this tissue by inhibiting PDE5, which is responsible for cGMP degradation in the cavernous body.

PDE5 inhibition by sildenafil influence results in increased cGMP levels in the cavernous body, resulting in smooth muscle relaxation and increased blood flow to cavernous body.

In some patients, after 1 hour after drug administration at a dose of 100 mg using the Farnsworth-Munsell 100 showed mild and transient impaired ability to distinguish between color shades (blue / green); 2 hours after receiving these changes disappear.

It is believed that color vision violation is caused by the inhibition of PDE6, which is involved in light transmission in the retina. Viagra has no effect on visual acuity, contrast perception, electroretinogram, intraocular pressure and pupil diameter.

Viagra Pharmacokinetics

My Canadian Pharmacy Viagra Pharmacokinetics depends on the dose – 25 mg to 100 mg per day.

Couple with My Canadian Pharmacy Viagra

Absorption into Blood

Sildenafil is rapidly absorbed. After taking in 100 mg of sildenafil limiting drug concentration in the blood is 18 ng / ml (38nM), while taking the drug without food reaches within half an hour to two hours minimum.

At the use of fatty foods, the intake of sildenafil in the blood increased by about half an hour, and the maximum concentration in the blood is reduced by 29%

Distribution

Sildenafil and its major inside circulating component approximately in 96% of cases bind to plasma protein. Sildenafil concentration has no effect on protein binding.

When receiving 100 mg of sildenafil, a half an hour after administration were detected as 0.0002% (average 188 ng) in sperm.

Metabolism

Basically Sildenafil Citrate is metabolized under the influence of CYP3A4 (major route) and CYP2C9 (minor route) – hepatic microsomal isoenzymes.

By productivity action on PDE metabolite comparable with sildenafil and its activity against PDE5 in vitro is approximately 50% of sildenafil activity.

The concentration of metabolite in plasma is approximately 40% of that of sildenafil.
happiness with Viagra

Clearance

The total clearance of sildenafil is 41 l / h, T1 / 2, in Therm. Phase – 3-5 hours. After oral Viagra clearance carries out in the form of metabolites in the feces of 80% and in the urine about 13% of the dose.

Indications

Erectile dysfunction (read more) is inability to achieve or maintain an erection necessary for normal sexual intercourse.
Viagra is effective only if there is natural sexual stimulation. Viagra is not intended for use by women, but there is Pink Female Viagra.

Dosage

The drug is taken orally.

The usual initial dose is 50 mg for an hour before intercourse. If lack of effect and side effects are observed, dosage can be increased to 100 mg or decreased to 25 mg.

Take no more than 1 time per day.
For elderly men dose adjustment is required.
In severe renal insufficiency, the dose was reduced to 25 mg. In renal insufficiency, mild or moderate dose adjustment is necessary.
In case of liver pathologies My Canadian Pharmacy Viagra dosage can be reduced to 25 mg.
When combined with ritonavir, the maximum dose of sildenafil should be 25 mg, no more than 1 time in 48 hours.

In a joint application with inhibitors of CYP3A4 isoenzyme (such as erythromycin, saquinavir, ketoconazole, itraconazole), the initial dose should be 25 mg.

To minimize the risk of postural hypotension in patients taking alpha blockers, should start taking Sildenafil only after hemodynamic stabilization is achieved. Feasibility of reducing starting sildenafil dose should be considered.

Side Effects

Side effects are usually considered mild.

The frequency of adverse events is increased with dose magnifying.

The most common side effects:

  • Nervous system headache (10.8%);
  • Cardiovascular system vasodilation (10.9%).

Common side effects:

  • dizziness (2.9 %);
  • blurred vision, changes in sensitivity to light (2.5%).

Digestive system:

  • dyspepsia (3.0 %);
  • chromatic vision (mild and transient, mostly change
    perception of color shades) (1.1 %);
  • Cardiovascular palpitations (1.0 %);
  • Respiratory rhinitis (nasal congestion) (2.1 %).

In case of Viagra overdose increases following side effects are observed:

  1. Immune System: hypersensitivity reactions (including rash).
  2. Cardiovascular system: tachycardia, decreased blood pressure, fainting, nasal hemorrhage.
  3. Digestive system: vomiting.
  4. Bodies: eye pain, eye redness / scleral injection.
  5. Reproductive system: prolonged erection and/or priapism.

Read with all the details about side effects caused by Viagra.

Contraindications for Viagra Intake

man with erectile dyfsunctionHypersensitivity and intolerance to Viagra components. My Canadian Pharmacy Viagra is contraindicated in men who take medications of nitric oxide, nitrates in any form because sildenafil enhances the hypotensive nitrates effect.

You should not take Generic Viagra if you suffer from the following diseases:

  • anatomical penis deformity;
  • cavernous fibrosis;
  • angulation;
  • Peyronie’s disease;
  • drepanocytemia;
  • multiple myeloma;
  • leukosis;
  • thrombocytopenia.

Other contraindications are:

  • diseases accompanied with bleeding;
  • aggravation of gastric and duodenal ulcer;
  • retinitis pigmentosa;
  • heart failure;
  • unstable angina;
  • previous myocardial infarction and blood stroke;
  • severe arrhythmia;
  • hypertension.

Information for Patients

To determine the causes of erectile dysfunction and define the correct treatment it is necessary to consult a doctor.

Sexual contact is not recommended for men with heart disease, unstable angina, myocardial infarction or stroke, arrhythmia, hypertension or hypotension. Be attentive at any kind of medication intake. All the possible medications are sold by My Canadian Pharmacy.

Go to Viagra overview (dosage, price and etc.)