Category: ED medications - Part 2

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Side Effects Caused by Piligy

The following side effects are reported in clinical studies which were observed frequently and were dose-related: nausea (11.0% and 22.2% when taking 30 mg and 60 mg of Canadian Priligy (Dapoxetine) respectively), dizziness (5.8% and 10.9%), headaches (5.6% and 8.8% ), diarrhea (3.5% and 6.9%), insomnia (2.1% and 3.9%), fatigue (2.0% and 4.1%). The most common phenomena, demanding treatment withdrawal were nausea (in 2.2% of patients) and dizziness (1.2%).

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Unwanted side-effects observed during clinical tests are listed below:

  • Psychiatric disorders:

    • anxiety, agitation, restlessness, abnormal dreams, decreased libido – often (>1/100 to <1/10);
    • depression, depressed mood, state of euphoria, mood changes, nervousness, apathy, lethargy, confusion, disorientation, abnormal thinking, somatosensory amplification, sleep disorders, initial insomnia, middle insomnia, nightmares, bruxism, loss of libido, anorgasmia – frequent (>1/1000 to <1/100);
  • Central nervous system disorders:

    • dizziness, headaches – very often (>1/10);
    • drowsiness, impaired concentration, tremor, paresthesia – often (>1/100 to <1/10);
    • syncope, including vasovagal syncope, postural dizziness, akathisia, dysgeusia, hypersomnia, lethargy, sedative state, depression of consciousness – frequent (>1/1000 to <1/100);
    • dizziness at physical exertion, suddenly falling asleep – rare (>1/10000 to <1/1000);
  • Organs of sight disorders:

    • blurred vision – often (>1/100 to <1/10);
    • mydriasis, eye pain, vision disorders – frequent (>1/1000 to <1/100);
  • Organs of hearing and labyrinth disorders:

    • tinnitus – often (> 1/100 to <1/10);
    • vertigo – frequent (> 1/1000 to <1/100);
  • Cardiovascular system disorders:

    • «flushes» of blood – often (>1/100 to <1/10);
    • termination of sinus node activity, sinus bradycardia, tachycardia, decreased blood pressure, systolic hypertension – frequent (>1/1000 to <1/100);
    • hot «flushes» – rare (> 1/10000 <1/1000);
  • Respiratory system disorders:

    • nasal congestion, yawning – often (>1/100 to <1/10); Digestive tract disorders: nausea – very often (>1/10);
    • diarrhea, vomiting, constipation, abdominal pain, dyspepsia, flatulence, stomach discomfort, bloating, dry mouth – often (>1/100 to <1/10);
  • Skin and subcutaneous tissue disorders:

    • hyperhidrosis – often (>1/100 to <1/10);
    • itching, cold sweat – frequent (>1/1000 to <1/100);
  • Reproductive system disorders:

    • erectile dysfunction – often (>1/100 to <1/10);
    • an absence of ejaculation, orgasm disturbance, including anorgasmia in men, male genitals paresthesia – frequent (>1/1000 to <1/100);
  • General condition:

    • weakness, irritability – often (>1/100 to <1/10);
    • fatigue, hot feeling, anxiety, malaise, the feeling of alcohol intoxication – frequent (>1/1000 to <1/100);
  • Changes in laboratory parameters:

    • increased blood pressure – often (>1/100 to <1/10);
    • increased heart rate, increased diastolic blood pressure, increased orthostatic blood pressure – frequent (>1/1000 to <1/100).

Individual Side Effects

Fainting with loss of consciousness, with bradycardia or termination of sinus node activity were observed in patients during Holter monitoring and have been reported in clinical studies. These adverse events are regarded as related to the use of the drug. Most of the cases occurred within first 3 hours after ingestion, after the first dose or associated with medical procedures (blood sampling, changes in body position, blood pressure measurement). Prodromal symptoms often preceded syncope.

The incidence of syncope and prodromal symptoms depends on the dosage which was demonstrated in patients treated with higher doses of the drug.

Effects of Drug Withdrawal

Priligy for premature ejaculation side effectsIn case of sudden cancellation of long-term use of selective serotonin reuptake inhibitors for chronic depressive disorders treatment, there were observed the following symptoms:

  • dysphoric state;
  • irritability;
  • agitation;
  • dizziness;
  • sensory disturbances (e. g., paresthesias);
  • anxiety;
  • confusion;
  • headaches;
  • lethargy;
  • emotional lability;
  • insomnia;
  • hypomania.

Safety results showed the higher incidence of withdrawal symptoms in the form of mild to moderate insomnia and dizziness after drug withdrawal after 62 days of application.

Dosage and Administration of Priligy (Dapoxetine)

The drug is intended for oral administration. Pills should be swallowed whole with at least one full glass of water. Priligy can be taken regardless of meals.

Adult men from 18 to 64 years

Recommended starting dosage for all men is 30 mg; this dose is taken 1 – 3 hours before planned sexual intercourse. In case of insufficient effect and good tolerance, dosage can be increased to 60 mg. Maximal recommended dosage intake frequency – 1 time in 24 hours.

Dosage for premature ejaculation treatment must assess risks and benefits of the drug after the first 4 weeks of treatment or after administration of 6 doses and should determine a risk-benefit ratio to continue taking a drug or not.

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Patients with impaired renal function

For patients with mild or moderately severe violation of renal function dosage adjustment is not required, but caution is advised. Canadian Priligy is not recommended for patients with severe renal impairment.

Patients with impaired hepatic function

For patients with mild hepatic dysfunction dosage adjustment is not required. This drug is contraindicated in patients with moderately severe and severe hepatic impairment (classes B and C according to Child-Pugh classification).

Patients with low CYP2D6 activity, concomitant use with active CYP2D6 inhibitors

Caution should be taken when increasing dosage up to 60 mg in individuals with low CYP2D6 activity or patients, simultaneously with Priligy (Dapoxetine) taking active CYP2D6 inhibitors.

Patients receiving active or moderately active CYP3A4 inhibitors

Simultaneous treatment with active CYP3A4 inhibitors is contraindicated. At simultaneous Priligy (Dapoxetine) drug reception with moderately active CYP3A4 inhibitors dosage should be reduced to 30 mg.

Overdose

priligy overdoseIn clinical tests, cases of overdose are not described.

Priligy dosage up to 240 mg (2 doses of 120 mg every 3 h) caused no unexpected adverse events. Generally, symptoms of SSRI overdose include serotonergic reactions, including drowsiness, gastrointestinal disorders (nausea, vomiting), tachycardia, tremor, excitement and dizziness.

In case of overdose, it is necessary to carry out standard maintenance therapy. Due to significant drug binding to plasma proteins and a large volume of dapoxetine hydrochloride distribution, forced diuresis, dialysis, hemoperfusion and blood transfusion are unlikely to be effective. The specific antidote is not known.

Priligy Compatibility with Alcohol

Priligy (Dapoxetine) from Canadian Pharmacy for premature ejaculation treatment contains highly active chemical compounds which, when combined with ethanol, cause pronounced deterioration in patient’s state of health. That is why experienced doctors warn men not to drink alcohol on the day of receiving this pharmacological agent. [ithshop code=”priligy” tpl=”short” page_id=”1351″ dummy=”txt”] Mechanism of Interaction with Alcohol Pharmacists claim an insufficient number of scientific works related to research of the harmful effect of alcohol in interaction…

Generic Dapoxetine vs. Original Priligy

Generic Dapoxetine – a potent prolongator for men. The drug of the latest generation hits right the target, without causing side effects, non-toxic, does not affect blood pressure and heart rate, has no age restrictions. Dapoxetine will provide a stable and long-lasting erection. You will forget about the problem of premature ejaculation and be able to have sex as much as you want. The prolongator in these pills is suitable for the unnoticeable reception. Its…

What is Priligy (Dapoxetine)?

Priligy is a medication belonging to the selective serotonin reuptake inhibitor devoted to premature ejaculation treatment.

History of Creation

The unexpected effect of the drug was discovered by accident, which unites it with famous Viagra. Pharmacologists of the world known «Johnson & Johnson»the company had a clear mission: to create a universal antidepressant, which regulates the circulation of the so-called «hormone of happiness» – serotonin – in the brain. Thus Priligy was born.

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Clinical trials were conducted with the participation of men aged from 18 to 60 years. It was observed that the drug eliminates depression because of its impact not only on neurotransmitters but also on sexual intercourse duration. The participants in the study, as well as clinicians themselves, were surprised to find such a pleasant property of the drug. It completely eliminates the problem of premature ejaculation, while multiplying pleasure from orgasm.

Of course, high efficiency and safety of this drug for the body should also be noted. Dapoxetine is rapidly absorbed by body and excreted during a few hours – it is its main difference from antidepressants, which removal process can take several days.

This PE drug has passed clinical trials in more than 22 countries around the world, in which it proved to be highly effective. It is able to delay orgasm and prolong sex by 3 – 4 times. It’s really overwhelming figures.

Also, it should be noted that dapoxetine is very well combined with pills for erectile dysfunction treatment – with Viagra, Levitra, Cialis, regardless of their dosage. Efficacy of the latter does not decrease.
Forget about Premature Ejaculation
Priligy active ingredient – dapoxetine, which increases serotonin level (natural chemical substance) that can slow process of ejaculation. It can also increase a sense of control over the ejaculation process and time. In the process of this medication application, increased time to ejaculation leads to increased feelings of control over ejaculation.

Mechanism of Action

It is assumed that dapoxetine action at premature ejaculation is associated with serotonin reuptake inhibition by neurons followed by neurotransmitter action amplification in pre- and post-synaptic receptors.

Ejaculation mechanism is mainly regulated by the sympathetic nervous system. Postganglionic sympathetic nerve fibers innervate seminal vesicles, deferent canal, prostate, urethra and muscles of the bladder neck, causing the coordinated contraction to achieve ejaculation. Dapoxetine affects ejaculation reflex, increasing latent period and reducing the duration of reflex impulses of perineum ganglia motoneurons. Stimulus triggering ejaculation is generated in a spinal reflex center which via brain stem is controlled by several brain nuclei including paraventricular and preoptic.

How to Use Priligy?

The main indication for Priligy is premature ejaculation. In addition, it well helps in daily therapy and has a significant impact on the emotional state of a person. If you have problems with sex, you suffer from premature ejaculation, this drug is for you. It will help to solve this problem and forget about it.

It should be taken properly and always according to instructions or advice of experts. Like any medicine, there are side effects and contraindications. It is categorically contraindicated to take the drug without a prescription. Only a doctor can prescribe this drug after medical examination and testing.

Causes of premature ejaculation can be different – you need to decide first whether you really need serotonin inhibitors. Of course, dosage regimen is also determined by a specialist. Based on conducted experiments, the drug gives an immediate and long-lasting effect. Instruction for use prohibits taking more than one pill per day. It is also necessary then to consider that effect of the drug appears after 30 – 60 minutes. Priligy can be used regardless of food.

It is necessary to exclude alcohol while taking the drug because alcoholic beverages can lower efficiency of medicine or cause unwanted adverse reactions. Its effect lasts for three to four hours. During therapy, patients are recommended to regularly visit the doctor, who will closely monitor changes in the body.

Canadian Pharmacy Priligy reviews

Modern medicine recommends taking the drug with caution to men who have suffered from mental alienation. Conditional contraindications include kidney diseases, coagulation disorders, epilepsy – in such cases, additional researches are needed.

Always follow rules of admission, follow instructions and do not break advice from your physician. This may have an opposite effect. And you, instead of enjoying life and sexual contact, will be hospitalized.

How does Viagra Act on Women

Often women and girls pay attention to products that do not have a specific action on their bodies. This is not due to health problems, but rather because of simple curiosity, desire to get new experience and stronger effect on intimacy. Does, in this case, desired positive result exist and is it safe for women to take such a drug as male Viagra? A Bit of History about Viagra It happened in the 20th century….

Types of Viagra

Viagra is the first drug that has been developed to recover potency and treat premature ejaculation. The drug is made on basis of a potent selective sildenafil reuptake inhibitor. Sildenafil is indicated to perform the following functions: qualitatively enhance blood circulation in the penis; cause a strong erection; suppress the premature release of seminal fluid.

What is Liquid Viagra?

Liquid Viagra is a drug for erectile dysfunction which works much faster because it is not in a coated tablet that needs to dissolve. This medication is an excellent method of maintaining male sexual activity.

How to Choose Drugs to Increase Potency

Impotence is a problem faced by many men. According to statistics, more than 200 million of men suffer from this disease, and in 10 years this number will be doubled. For 20% of them, sexual contacts occur not more than once or twice a week, lasting about three to four minutes.

Natural Viagra

Viagra is a drug for healthy erection restoration and premature ejaculation elimination. This drug works quickly and maintains its positive effect for three to four hours. The main component is sildenafil – selective inhibitor, which slows down PDE-5 enzyme work and prolongs an erection. This drug is effective at first symptoms of impotence but it has a number of contraindications and may cause side effects. In addition, small amounts of sildenafil accumulate in blood plasma. Also,…