Cipro Interactions with Other Drugs

Cipro interactions may change the effect of medications or increase the risk of side effects. This article does not list all possible interactions. Consult your doctor and pharmacist before using this medication from Canadian Pharmacy. Do not take any drugs without your doctor’s prescription.

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Drug Interactions

  • Due to microsomal oxidation decreased activity in hepatocytes, Cipro increases concentration and prolongs half-life period of theophylline and other xanthines (e. g., caffeine), oral hypoglycemic drugs, indirect anticoagulants, thereby reducing prothrombin ratio;
  • Applied together with NSAIDs (except for acetylsalicylic acid), the antibiotic increases seizures risk;
  • Metoclopramide accelerates ciprofloxacin absorption, which reduces time to achieving the maximal concentration of the latter;
  • Co-administration with uricosuric drugs leads to slower excretion (up to 50%) and increased the concentration of the antibiotic in plasma;
  • When combined with other antimicrobial agents (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergism is commonly observed;
  • The antibiotic increases cyclosporine nephrotoxic effect, there also noted an increase in serum creatinine, therefore these patients should control this indicator 2 times a week;
  • At the same time, this medication increases indirect anticoagulants effect;
  • Ciprofloxacin clearance is slowed down when taking probenecid;
  • Cipro solution is pharmaceutically incompatible with all infusion solutions and drugs that are physic-chemically unstable at acidic environment (Ciprofloxacin infusion solution pH – 3,5 – 4,6). You must not mix solution for intravenous administration with solutions having pH greater than 7.
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