Canadian Pharmacy Amoxicillin is a semi-synthetic antibacterial penicillin drug. According to some reports Amoxicillin is one of the most commonly prescribed antibiotics for treating children.
The drug was synthesized by «Beecham» British company scientists in 1960. After 12 years, during which clinical trials of new means were held, Amoxicillin became available for sale. It became second semi-synthetic penicillin drug after ampicillin, developed in 1961.
Today we can surely say that Amoxicillin achievements are huge: 42 years later antibiotic is still used throughout the world. The World Health Organization (http://www.who.int/en/) has included this drug in the list of essential medicines that are necessary in healthcare system. Often pediatricians prefer it the old, but secure Canadian Amoxicillin. At the same time gradually number of frustrated doctors and patients increases, who did not receive desired effect or, conversely, received unexpected result.
In this article My Canadian Pharmacy team will try to understand how justified expectations of those who wholeheartedly believe in Amoxicillin power. Whether the drug is safe, and most importantly – is it always effective?
Fast Facts: Amoxicillin Structure and Pharmacological Effect
Amoxicillin composition includes one single active substance: amoxicillin trihydrate, which is an ampicillin analog with modified formula.
Penicillins pharmacological effect is based on their ability to break sensitive bacteria cell wall synthesis.
Amoxicillin Canada pharmacological activity spectrum is wide. Among microorganisms, that are sensitive to the drug, there are:
- aerobic gram-positive staphylococci and streptococci;
- gram-negative gonorrhea, E. coli, Shigella, Salmonella and Klebsiella pathogens.
Penicillinase and Amoxicillin, or When Antibiotics Won’t Help
Penicillins descriptions and comments often give not quite understandable term – penicillinase or beta-lactamase. Let’s try to understand pharmacology finest points and understand this mysterious substance effect on antibiotic effectiveness.
Penicillins have been used for almost 80 years. During this time, some kinds of «creative» pathogenic bacteria have learned to resist, synthesizing penicillinase – enzyme of beta-lactamase group. It is able to destroy penicillin and cephalosporin antibiotics, which contain in their structure beta-lactam ring. As a result, drugs are completely inactivated and bacteria continue to exist.
Canada Pharmacy Amoxicillin, as other penicillin antibiotics, is inactive against microorganisms that produce penicillinase. Non-sensitive bacteria include some strains of staphylococci, a lot of gram-negative organisms.
Penicillinase and Clavulanic Acid: Irreconcilable Enemies
Ability of a wide range of microorganisms to safely resist amoxicillin effect was discovered during clinical trials. British pharmacists of «Beecham» company-developer began active search for «antidote» against penicillinases, bringing to nothing antibiotics effectiveness.
In the late 70-ies the solution was found. Clavulanic acid and some of its compounds have proved able to prevent enzymes destructive action. These substances strongly seize penicillinase forming a stable complex with them, and give Canadian Amoxicillin opportunity to work.
Complex with clavulanate is able to affect a much greater number of pathogenic microorganisms than pure antibiotic. It should be emphasize that amoxicillin and clavulanic acid combination is a new drug that is available under various trade names.
All unprotected antibiotics containing only one component composition, remain vulnerable to beta-lactamase. Therefore, it should be once again noticed that hasty decision to start self-medication with antibiotics is unacceptable. Each group of antibiotics has its own characteristics that are important to consider. And only doctor can appoint antibiotic that will bring relief.
So Different Amoxicillin: Pharmaceutical Forms
Amoxicillin Canadian Pharmacy relates to drugs which are available in a variety of dosages and pharmaceutical forms. Companies, producing medicines, try to create their own, most «convenient» drug.
So, let’s try to understand what Amoxicillin form can be purchased in pharmacies. Pharmaceutical companies release the following forms of popular antibiotic:
- Amoxicillin children suspension in dosages of 125 mg and 250 mg;
- Amoxicillin pills or capsules of 250 mg, 500 mg and 1000 mg;
It should be noted that amoxicillin, as well as most antibiotics, is a substance that when dissolved is not able to keep their chemical and physical properties. Therefore, suspension is also produced in the form of powder or granules that are to be dissolved before use.
Indications for Use – What does Amoxicillin Treat?
Canadian Amoxicillin antibiotic is indicated for the following pathological conditions:
- upper respiratory tract infections – sinusitis (sinuses inflammation), pharyngitis (throat disease), laryngitis (larynx and vocal cords inflammation);
- tracheitis (trachea inflammation), bronchitis (bronchi infection) and pneumonia (lungs inflammation);
- tonsillitis (tonsils inflammation) and otitis (pathological process in middle ear);
- amoxicillin pills are prescribed for urinary tract and genital organs infections (acute and chronic pyelonephritis, cystitis, endometritis);
- a very specific disease – gonorrhea – is also treated with this disease;
- the drug is effective for skin diseases – erysipelas and impetigo, caused by streptococcal infection;
- Amoxicillin antibiotic is widely prescribed for intestinal tract diseases;
- Penicillins remain drug of choice for meningitis treatment;
- antibiotics of this group are applied at listeriosis, borreliosis and leptospirosis;
- it is also appointed at sepsis;
- Canadian Amoxicillin is a part of gastric and duodenal ulcer complex therapy.
Stop Antibiotic, or When Amoxicillin shouldn’t be Used
One of domestic medicine major problems is lack of proper control over prescription drugs release. Until now, most pharmacies sell a lot of drugs without prescription.
Often, patients buy antibiotics «from memory», having once used this drug and received positive effect. Sometimes such choice is made according to advice. It is noteworthy that about 70% of self-medication with antibiotics cases is not justified.
Among cases of unjustified Amoxicillin application a special place is occupied by viral infections. Antibiotics have absolutely no effect on viruses. Meanwhile, the majority of seasonal diseases are not related to bacteria.
What diseases are initially of viral origin? These are, of course, primarily influenza and ARVI (acute respiratory viral infection). Moreover, the majority of pharyngitis, rhinitis, tracheitis and bronchitis are also caused by different viruses. That is why so often we do not see effect after taking antibiotics for these diseases.
So, Canadian Pharmacy Amoxicillin, like any other antibacterial drug, is not used for viral infections. To distinguish disease caused by bacteria and viruses, for people, who have nothing to do with medicine, it is very difficult. It is a pity to note, but even doctors sometimes do not differentiate these pathogens. As a result, a number of unjustified antibiotics use is growing, and at the same time new strains of drug-resistant bacteria appear.
Despite rather respectable Amoxicillin age, doctors’ reviews on this drug are usually positive. Doctors are unanimous in one thing: when appointed correctly, it really works well. However, considering possibility of certain bacteria strains persistence, Canadian Amoxicillin should be prescribed by doctors. And initiative in such a delicate matter as antibiotic choice is unacceptable.