Tag: erectile dysfunction

[ithshop code=”priligy” tpl=”short” page_id=”1351″ dummy=”txt”] The following drugs can’t be combined with Canadian Priligy: Interactions with MAO inhibitors Patients receiving both SSRI and MAO inhibitors observed serious, sometimes fatal reactions, including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of the system of vital functions indicators and mental state changes including strong agitation, progressing into delirium and coma. These reactions have also been observed in patients who have recently withdrawn SSRIs and started treatment…

Take Priligy with caution in the following cases: hypersensitivity to dapoxetine hydrochloride or any drug component; expressed heart diseases (e. g., cardiac insufficiency of II-IV class according to NYHA, disturbances of cardiac conduction (AV-block of 2-3 degrees or SSS) in absence of permanent cardiac pacemaker, severe ischemic heart disease or valvular lesion); concomitant use of MAO inhibitors and within 14 days after their application cessation. Likewise, MAO inhibitors should not be taken within 7 days after drug…

The following side effects are reported in clinical studies which were observed frequently and were dose-related: nausea (11.0% and 22.2% when taking 30 mg and 60 mg of Canadian Priligy (Dapoxetine) respectively), dizziness (5.8% and 10.9%), headaches (5.6% and 8.8% ), diarrhea (3.5% and 6.9%), insomnia (2.1% and 3.9%), fatigue (2.0% and 4.1%). The most common phenomena, demanding treatment withdrawal were nausea (in 2.2% of patients) and dizziness (1.2%).

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Unwanted side-effects observed during clinical tests are listed below:

• Psychiatric disorders:
  • anxiety, agitation, restlessness, abnormal dreams, decreased libido – often (>1/100 to <1/10);
  • depression, depressed mood, state of euphoria, mood changes, nervousness, apathy, lethargy, confusion, disorientation, abnormal thinking, somatosensory amplification, sleep disorders, initial insomnia, middle insomnia, nightmares, bruxism, loss of libido, anorgasmia – frequent (>1/1000 to <1/100);
• Central nervous system disorders:
  • dizziness, headaches – very often (>1/10);
  • drowsiness, impaired concentration, tremor, paresthesia – often (>1/100 to <1/10);
  • syncope, including vasovagal syncope, postural dizziness, akathisia, dysgeusia, hypersomnia, lethargy, sedative state, depression of consciousness – frequent (>1/1000 to <1/100);
  • dizziness at physical exertion, suddenly falling asleep – rare (>1/10000 to <1/1000);
• Organs of sight disorders:
  • blurred vision – often (>1/100 to <1/10);
  • mydriasis, eye pain, vision disorders – frequent (>1/1000 to <1/100);
• Organs of hearing and labyrinth disorders:
  • tinnitus – often (> 1/100 to <1/10);
  • vertigo – frequent (> 1/1000 to <1/100);
• Cardiovascular system disorders:
  • «flushes» of blood – often (>1/100 to <1/10);
  • termination of sinus node activity, sinus bradycardia, tachycardia, decreased blood pressure, systolic hypertension – frequent (>1/1000 to <1/100);
  • hot «flushes» – rare (> 1/10000 <1/1000);
• Respiratory system disorders:
  • nasal congestion, yawning – often (>1/100 to <1/10); Digestive tract disorders: nausea – very often (>1/10);
  • diarrhea, vomiting, constipation, abdominal pain, dyspepsia, flatulence, stomach discomfort, bloating, dry mouth – often (>1/100 to <1/10);
• Skin and subcutaneous tissue disorders:
  • hyperhidrosis – often (>1/100 to <1/10);
  • itching, cold sweat – frequent (>1/1000 to <1/100);
• Reproductive system disorders:
  • erectile dysfunction – often (>1/100 to <1/10);
  • an absence of ejaculation, orgasm disturbance, including anorgasmia in men, male genitals paresthesia – frequent (>1/1000 to <1/100);
• General condition:
  • weakness, irritability – often (>1/100 to <1/10);
  • fatigue, hot feeling, anxiety, malaise, the feeling of alcohol intoxication – frequent (>1/1000 to <1/100);
• Changes in laboratory parameters:
  • increased blood pressure – often (>1/100 to <1/10);
  • increased heart rate, increased diastolic blood pressure, increased orthostatic blood pressure – frequent (>1/1000 to <1/100).

Individual Side Effects

Fainting with loss of consciousness, with bradycardia or termination of sinus node activity were observed in patients during Holter monitoring and have been reported in clinical studies. These adverse events are regarded as related to the use of the drug. Most of the cases occurred within first 3 hours after ingestion, after the first dose or associated with medical procedures (blood sampling, changes in body position, blood pressure measurement). Prodromal symptoms often preceded syncope.

The incidence of syncope and prodromal symptoms depends on the dosage which was demonstrated in patients treated with higher doses of the drug.

Effects of Drug Withdrawal

In case of sudden cancellation of long-term use of selective serotonin reuptake inhibitors for chronic depressive disorders treatment, there were observed the following symptoms:

• dysphoric state;
• irritability;
• agitation;
• dizziness;
• sensory disturbances (e. g., paresthesias);
• anxiety;
• confusion;
• headaches;
• lethargy;
• emotional lability;
• insomnia;
• hypomania.

Safety results showed the higher incidence of withdrawal symptoms in the form of mild to moderate insomnia and dizziness after drug withdrawal after 62 days of application.

The drug is intended for oral administration. Pills should be swallowed whole with at least one full glass of water. Priligy can be taken regardless of meals.

Adult men from 18 to 64 years

Recommended starting dosage for all men is 30 mg; this dose is taken 1 – 3 hours before planned sexual intercourse. In case of insufficient effect and good tolerance, dosage can be increased to 60 mg. Maximal recommended dosage intake frequency – 1 time in 24 hours.

Dosage for premature ejaculation treatment must assess risks and benefits of the drug after the first 4 weeks of treatment or after administration of 6 doses and should determine a risk-benefit ratio to continue taking a drug or not.

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Patients with impaired renal function

For patients with mild or moderately severe violation of renal function dosage adjustment is not required, but caution is advised. Canadian Priligy is not recommended for patients with severe renal impairment.

Patients with impaired hepatic function

For patients with mild hepatic dysfunction dosage adjustment is not required. This drug is contraindicated in patients with moderately severe and severe hepatic impairment (classes B and C according to Child-Pugh classification).

Patients with low CYP2D6 activity, concomitant use with active CYP2D6 inhibitors

Caution should be taken when increasing dosage up to 60 mg in individuals with low CYP2D6 activity or patients, simultaneously with Priligy (Dapoxetine) taking active CYP2D6 inhibitors.

Patients receiving active or moderately active CYP3A4 inhibitors

Simultaneous treatment with active CYP3A4 inhibitors is contraindicated. At simultaneous Priligy (Dapoxetine) drug reception with moderately active CYP3A4 inhibitors dosage should be reduced to 30 mg.

Overdose

In clinical tests, cases of overdose are not described.

Priligy dosage up to 240 mg (2 doses of 120 mg every 3 h) caused no unexpected adverse events. Generally, symptoms of SSRI overdose include serotonergic reactions, including drowsiness, gastrointestinal disorders (nausea, vomiting), tachycardia, tremor, excitement and dizziness.

In case of overdose, it is necessary to carry out standard maintenance therapy. Due to significant drug binding to plasma proteins and a large volume of dapoxetine hydrochloride distribution, forced diuresis, dialysis, hemoperfusion and blood transfusion are unlikely to be effective. The specific antidote is not known.

Priligy (Dapoxetine) from Canadian Pharmacy for premature ejaculation treatment contains highly active chemical compounds which, when combined with ethanol, cause pronounced deterioration in patient’s state of health. That is why experienced doctors warn men not to drink alcohol on the day of receiving this pharmacological agent. [ithshop code=”priligy” tpl=”short” page_id=”1351″ dummy=”txt”] Mechanism of Interaction with Alcohol Pharmacists claim an insufficient number of scientific works related to research of the harmful effect of alcohol in interaction…

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